Arrhythmogenesis Toxicity of Aconitine Is Related to Intracellular Ca2+ Signals

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Arrhythmogenesis Toxicity of Aconitine Is Related to Intracellular Ca2+ Signals

Aconitine is a well-known arrhythmogenic toxin and induces triggered activities through cardiac voltage-gated Na(+) channels. However, the effects of aconitine on intracellular Ca(2+) signals were previously unknown. We investigated the effects of aconitine on intracellular Ca(2+) signals in rat ventricular myocytes and explored the possible mechanism of arrhythmogenic toxicity induced by aconi...

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ژورنال

عنوان ژورنال: International Journal of Medical Sciences

سال: 2013

ISSN: 1449-1907

DOI: 10.7150/ijms.6541